{"id":826404,"date":"2026-05-26T13:30:35","date_gmt":"2026-05-26T17:30:35","guid":{"rendered":"https:\/\/mymodernmet.com\/?p=826404"},"modified":"2026-05-26T12:25:30","modified_gmt":"2026-05-26T16:25:30","slug":"stanford-regrow-aging-knee-cartilage","status":"publish","type":"post","link":"https:\/\/mymodernmet.com\/stanford-regrow-aging-knee-cartilage\/","title":{"rendered":"Scientists at Stanford Find a Way To Regrow Aging Knee Cartilage and Prevent Arthritis"},"content":{"rendered":"<div id=\"attachment_826414\" style=\"width: 810px\" class=\"wp-caption alignnone\"><noscript><img decoding=\"async\" aria-describedby=\"caption-attachment-826414\" class=\"lazyload size-full wp-image-826414\" src=\"https:\/\/mymodernmet.com\/wp\/wp-content\/uploads\/2026\/05\/anti-aging-injection-knee-cartilage-1.jpg\" alt=\"Illustration depicting knee pain\" width=\"800\" height=\"533\" srcset=\"https:\/\/mymodernmet.com\/wp\/wp-content\/uploads\/2026\/05\/anti-aging-injection-knee-cartilage-1.jpg 800w, https:\/\/mymodernmet.com\/wp\/wp-content\/uploads\/2026\/05\/anti-aging-injection-knee-cartilage-1-300x200.jpg 300w, https:\/\/mymodernmet.com\/wp\/wp-content\/uploads\/2026\/05\/anti-aging-injection-knee-cartilage-1-768x512.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/noscript><img decoding=\"async\" aria-describedby=\"caption-attachment-826414\" class=\"lazyload size-full wp-image-826414\" src=\"data:image\/svg+xml,&lt;svg xmlns=&quot;http:\/\/www.w3.org\/2000\/svg&quot; viewBox=&quot;0 0 800 533&quot;&gt;&lt;\/svg&gt;\" data-src=\"https:\/\/mymodernmet.com\/wp\/wp-content\/uploads\/2026\/05\/anti-aging-injection-knee-cartilage-1.jpg\" alt=\"Illustration depicting knee pain\" width=\"800\" height=\"533\" data-srcset=\"https:\/\/mymodernmet.com\/wp\/wp-content\/uploads\/2026\/05\/anti-aging-injection-knee-cartilage-1.jpg 800w, https:\/\/mymodernmet.com\/wp\/wp-content\/uploads\/2026\/05\/anti-aging-injection-knee-cartilage-1-300x200.jpg 300w, https:\/\/mymodernmet.com\/wp\/wp-content\/uploads\/2026\/05\/anti-aging-injection-knee-cartilage-1-768x512.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><p id=\"caption-attachment-826414\" class=\"wp-caption-text\">Photo: pixologic\/<a href=\"https:\/\/depositphotos.com\/\" target=\"_blank\" rel=\"noopener\">Depositphotos<\/a><\/p><\/div>\n<p>According to the <a href=\"https:\/\/www.cdc.gov\/cdi\/indicator-definitions\/arthritis.html\" target=\"_blank\" rel=\"noopener\">Centers for Disease Control and Prevention<\/a>, about 53 million U.S. adults have arthritis, and that number is expected to increase as people live longer. This incurable condition affects the joints and the tissues around them. As such, managing symptoms is key to reducing pain and improving the quality of life for patients. One of the latest efforts in the crusade against this condition comes from <a href=\"https:\/\/med.stanford.edu\/news\/all-news\/2025\/11\/joint-cartilage-aging.html\" target=\"_blank\" rel=\"noopener\">Stanford University<\/a>, where scientists found a way to regrow aging cartilage, raising hopes for arthritis treatments.<\/p>\n<p>The team, led by Helen Blau, PhD, professor of microbiology and immunology, and Nidhi Bhutani, PhD, associate professor of orthopaedic surgery, tested an injection that blocks the activity of a <em>gerozyme<\/em>, a protein involved in aging, known as 15-PGDH. This targets the cause of osteoarthritis, the most common kind of arthritis, in which the protective cartilage that cushions the ends of the bones wears down as we grow old.<\/p>\n<p>The animal-tested treatment blocked the function of 15-PGDH with a small molecule, resulting in an increase in old mice&rsquo;s muscle mass and endurance, reversing the naturally occurring cartilage loss in the knee joints of animals. It was also tested on samples of human tissue from knee replacement surgeries, where it also responded by making new, functional cartilage. The scientists also found that the injection also prevented the development of arthritis after knee injuries, such as ACL tears.<\/p>\n<p>&ldquo;Millions of people suffer from joint pain and swelling as they age,&rdquo; Bhutani told Stanford Medicine. &ldquo;It is a huge unmet medical need. Until now, there has been no drug that directly treats the cause of cartilage loss. But this gerozyme inhibitor causes a dramatic regeneration of cartilage beyond that reported in response to any other drug or intervention.&rdquo;<\/p>\n<p>&ldquo;This is a new way of regenerating adult tissue, and it has significant clinical promise for treating arthritis due to aging or injury,&rdquo; Blau added. &ldquo;We were looking for stem cells, but they are clearly not involved. It&rsquo;s very exciting.&rdquo;<\/p>\n<p>Now, it is reported than an oral version of the treatment is in clinical trials. With some luck, it will become a reliable resource in treating age-related muscle weakness that affects so many people.\n<\/p>\n<h4><em>Sources: <a href=\"https:\/\/med.stanford.edu\/news\/all-news\/2025\/11\/joint-cartilage-aging.html\" target=\"_blank\" rel=\"noopener\">Inhibiting a master regulator of aging regenerates joint cartilage in mice<\/a><\/em><\/h4>\n<h2><span style=\"text-decoration: underline;\">Related Articles<\/span>:<\/h2>\n<p><a href=\"https:\/\/mymodernmet.com\/eukaryotic-cell-digizyme\/\">Scientists Visualize the Complex, Dynamic World Inside a Human Cell<\/a><\/p>\n<p><a href=\"https:\/\/mymodernmet.com\/loy-002-longevity-drug-for-dogs\/\">Scientists Are Developing a First-Of-Its-Kind Pill To Help Dogs Live Longer<\/a><\/p>\n<p><a href=\"https:\/\/mymodernmet.com\/repawse-exoskeleton-assistive-dog-walking-technology\/\">Innovative Exoskeleton Designed To Help Injured and Disabled Dogs Walk Again<\/a><\/p>\n<p><a href=\"https:\/\/mymodernmet.com\/alzheimers-disease-walking\/\">New Study Suggests Alzheimer&rsquo;s Disease Could Be Slowed by Walking 5,000 Steps a Day<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>According to the Centers for Disease Control and Prevention, about 53 million U.S. adults have arthritis, and that number is expected to increase as people live longer. This incurable condition affects the joints and the tissues around them. As such, managing symptoms is key to reducing pain and improving the quality of life for patients. [&hellip;]<\/p>\n","protected":false},"author":1294,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_wp_convertkit_post_meta":{"form":"-1","landing_page":"0","tag":"0","restrict_content":"0"},"_ef_editorial_meta_date_first-draft-date":"","_ef_editorial_meta_paragraph_assignment":"","_ef_editorial_meta_checkbox_needs-photo":"","_ef_editorial_meta_number_word-count":"","footnotes":""},"categories":[373666],"tags":[406192,406191,400198],"class_list":["post-826404","post","type-post","status-publish","format-standard","hentry","category-health","tag-arthritis","tag-cartilage","tag-stanford"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Scientists at Stanford Find a Way to Regrow Aging Knee Cartilage<\/title>\n<meta name=\"description\" content=\"Scientists at Stanford University found a way to regrow aging cartilage, raising hopes for arthritis treatments.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mymodernmet.com\/stanford-regrow-aging-knee-cartilage\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists at Stanford Find a Way To Regrow Aging Knee Cartilage and Prevent Arthritis\" \/>\n<meta property=\"og:description\" content=\"Millions of people suffer from cartilage loss and arthritis. This could be a breakthrough to relieve a lot of pain and suffering.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mymodernmet.com\/stanford-regrow-aging-knee-cartilage\/\" \/>\n<meta property=\"og:site_name\" content=\"My Modern Met\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/mymodernmet\" \/>\n<meta property=\"article:published_time\" content=\"2026-05-26T17:30:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mymodernmet.com\/wp\/wp-content\/uploads\/2026\/05\/anti-aging-injection-knee-cartilage-fb.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Regina Sienra\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Scientists Find Way to Regrow Aging Knee Cartilage &amp; Prevent Arthritis\" 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She is a Mexico City-based journalist, translator, and digital media professional with over a decade of experience creating bilingual content in English and Spanish. She holds a bachelor\u2019s degree in Communications with a specialization in Journalism from the National Autonomous University of Mexico. Her work spans both hard and soft news, with a focus on arts, culture, and entertainment. She has a particular interest in highlighting emerging and independent musicians, a passion that earned her recognition as CBC Radio 3\u2019s Fan of the Year in 2014. Sienra brings a broad pop culture perspective to her writing, with interests that include music, film, and cultural trends across media. When she isn't writing, she is watching films, attending concerts, and building out her growing vinyl collection.","url":"https:\/\/mymodernmet.com\/author\/regina-sienra\/"}]}},"_links":{"self":[{"href":"https:\/\/mymodernmet.com\/wp-json\/wp\/v2\/posts\/826404","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mymodernmet.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mymodernmet.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mymodernmet.com\/wp-json\/wp\/v2\/users\/1294"}],"replies":[{"embeddable":true,"href":"https:\/\/mymodernmet.com\/wp-json\/wp\/v2\/comments?post=826404"}],"version-history":[{"count":19,"href":"https:\/\/mymodernmet.com\/wp-json\/wp\/v2\/posts\/826404\/revisions"}],"predecessor-version":[{"id":826448,"href":"https:\/\/mymodernmet.com\/wp-json\/wp\/v2\/posts\/826404\/revisions\/826448"}],"wp:attachment":[{"href":"https:\/\/mymodernmet.com\/wp-json\/wp\/v2\/media?parent=826404"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mymodernmet.com\/wp-json\/wp\/v2\/categories?post=826404"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mymodernmet.com\/wp-json\/wp\/v2\/tags?post=826404"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}